Essay / Sep 2026
Life at the Limit: The Economics of Cheating Death
What a year of life is actually worth, how to bend the aging curve, and why the shape of the longevity prize may matter more than its size.
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Writing & conversations
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Essays on science and company building. Conversations with the people pushing both forward.
35 essays & episodes Newest first
Essay / Dec 11, 2023
Why Prime Movers Lab Invested in Zafrens
Prime Movers Lab leads Series A for massively parallel multi-modality drug discovery platform company Zafrens.The speed of drug discovery is limited by our ability to generate experimental data. To design a…
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Essay / Oct 24, 2023
Why Prime Movers Lab Invested in LyGenesis
Prime Movers Lab leads $19M Series A round for organ regeneration cell therapy startup LyGenesis.The future of cell therapy and transplant medicine could have a new and unlikely hero: a patient’s own lymph…
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Essay / May 08, 2023
Diagnosing the Future: Prime Movers Labs predicts Medical Diagnostics breakthroughs to year 2050
At Prime Movers Lab, we back scientific entrepreneurs progressing breakthrough science with the potential to impact billions of lives. PML…
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Essay / Feb 15, 2023
Why Prime Movers Lab Invested in Morphoceuticals
Prime Movers Lab leads limb regeneration startup Morphoceuticals’ Seed Round with Juvenescence.
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Essay / Feb 01, 2023
Why We Invested in Dimension Inx
Prime Movers Lab leads Series A in leading tissue engineering company Dimension Inx.
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Essay / Jan 13, 2023
At the Limits of Detection: Prime Movers Lab launches Health Diagnostics Squad
Venture capital investing is a bit like walking around at midnight, or blindfolded. You know where you want to go. You are physically able…
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Essay / Jun 17, 2022
Longevity: The Battle of Aging as Disease
Two things in life are certain: death and taxes. Or so the saying goes. A growing number of scientists are chipping away at the very…
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Podcast / Dec 03, 2021
NFTs and the Art of Drug Development
On this episode, our guest is economist Paul Kohlhaas, co-founder and CEO of Molecule and co-author of the VitaDAO whitepaper. We’ll head to Berlin, Germany, where Paul and his team of scientists, engineers,…
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Podcast / Oct 21, 2021
From Bile to Trial - Ochre Bio
On this episode, Ochre Bio co-founders join us to discuss turning discarded organs into a goldmine of biological insight with deep phenotypics that enables the company to pan for fine-grained expression of all…
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Podcast / Sep 15, 2021
Human on a Chip - Emulate
On this episode we’ll meet Dr. Daniel Levner, co-founder and Chief Technology Officer at Emulate, a company commercializing technology to remake human biology from the ground up using small rubbery…
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Podcast / May 31, 2021
The Autonomous Lab - Arctoris
On this episode we’ll meet Thomas Fleming, Oxford-trained engineer, and co-founder and Chief Operating Officer of Arctoris a company that has developed a fully-autonomous drug discovery laboratory. Founded in…
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Podcast / Apr 30, 2021
The Mind's API - Rune Labs
On this episode we’ll take a walk, literally, with the founder and CEO of Rune Labs, Brian Pepin. Brian previously led electroceuticals development at GSK-backed Galvani, built a glucose-sensing contact lens…
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Podcast / Mar 30, 2021
Virtual Recovery - Prof John Krakauer
In flash, a stroke can have devastating consequences. Improving recovery outcomes will require new thinking. My grandmother’s stroke years ago shook my family. I saw her in fits over the loss of precious…
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Podcast / Oct 05, 2020
Breaking the Synthesis Barrier - Postera
How do you make a molecule? We’ve talked before on the TomorrowScale podcast about the challenges facing chemists–the “synthesis barrier.” The creation of novel materials and the discovery of small molecule…
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Podcast / Aug 14, 2020
The Last Interface - Paradromics
The development of brain-machine or brain-computer interfaces (BCIs) approaches an inflection point; not just in the pace of BCI progress, but also the capabilities and willingness to explore the field of…
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Podcast / Jun 26, 2020
On-Demand Biology - Tierra Biosciences
How do you build biology? Simple: DNA to RNA to proteins, right? Not so fast. Each one of your trillions of cells are themselves little factories, constantly producing various peptides and proteins that your…
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Podcast / Jun 11, 2020
Nature's Nuclear - Oklo, Inc.
On this episode Oklo co-founders Jacob DeWitte and Caroline Cochran join us to discuss what it took to get their startup to this point in development of the first advanced nuclear fission power plant; how a…
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Podcast / May 28, 2020
Trials to Your Door - Sanguine Biosciences
At the center of every clinical trial is a group of patients, each with a medical condition that we seek to understand more about through interacting with those patients directly. Startups like Sanguine…
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Podcast / May 13, 2020
Your Digital Twin - UnlearnAI
On this episode we’ll meet biophysicist, machine learning researcher, and CEO of UnlearnAI Dr. Charles Fisher. He and the team at Unlearn have the goal to build the entire biomedical machine learning stack,…
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Podcast / May 07, 2020
The Measure of Medicine - Prof Frank Lichtenberg
On this show we talk a lot about the opportunity and the promise of innovation. It is incredibly difficult, however, to study the actual impact of those new technologies. In healthcare, we do have some chance…
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Podcast / Apr 28, 2020
Computing the Universe - Jonathan Gorard, Wolfram Physics Project
On this episode, we’ll speak with one of the principal researchers on the Wolfram Physics Project, Jonathan Gorard. We’ll discuss how they plan to actually implement their “fundamental theory of the universe”…
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Podcast / Apr 15, 2020
Accelerating Evolution - Prof Chang Liu
Dr. Chang Liu, assistant professor of biomedical engineering at the University of California, Irvine, has transformed traditional yeast culture methods into an engine to accelerate evolution in order to…
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Podcast / Apr 02, 2020
Chemification - Prof Lee Cronin
In the beginning, there was chemistry. Well, not exactly. From those primordial reaction conditions … life emerged. But how? What separates chemistry from biology? How do we study the origin of life? What can…
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Podcast / Mar 25, 2020
Building a Brain - Rain Neuromorphics
What does the future of scientific computing look like? Labs all over the world are racing to build chips based on our brains. But what can it do? And what will it be used for? On this episode, we’ll meet a…
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Podcast / Mar 15, 2020
Engineering the (Immune) System - DistributedBio
On this episode we sit down with star scientists from Netflix’s show ‘Pandemic,’ DistributedBio co-founder and CEO Jacob Glanville, and Centivax program lead and director of contract research Sarah Ives. We’ll…
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Podcast / Feb 26, 2020
Information Therapeutics - Oisin Biotechnologies & OncoSenX
Drugs are getting smarter. A new wave of companies, including those founded by our guest, Matthew Scholz of Oisin Biotechnologies and OncoSenX, ride on recent advances in drug and gene delivery that are…
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Podcast / Feb 17, 2020
Reading Between the Scans - AIQ Solutions
The ability to visualize disease is vital to many parts of patient care. On this episode, we’ll meet AIQ Solutions, a company that is taking a long-term view of a patient’s response to cancer treatment using…
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Podcast / Feb 06, 2020
Generating Discoveries in Days - InSilico Medicine
Drug discovery is changing. Deep generative models, as being pioneered by our guest Dr. Alex Zhavoronkov, founder and CEO of InSilico Medicine, are able to generate entirely new molecules and even, as we’ll…
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Podcast / Jan 13, 2020
Medicine from Microbes - Lodo Therapeutics
On this episode, we’ll hear about Lodo and their plan to discover medicine from microbes. This is the TomorrowScale Podcast. Hosted by Justin Briggs. Lodo Therapeutics is a drug discovery company based in New…
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Podcast / Jan 03, 2020
Proof of Prophylaxis - MIT Langer Lab
Vaccines save lives. Yet, despite concerted global efforts more than 1.5 million children die each year from vaccine preventable diseases. The Bill & Melinda Gates Foundation are at the center of this massive…
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Podcast / Nov 20, 2019
Life from Light - Prellis Biologics
On this episode, we’ll meet Melanie Matheu, Ph.D., a scientist turning light into life. Her company, Prellis Biologics, has developed what may be a defining technology for the bioprinting industry: A method to…
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Podcast / Oct 20, 2019
Harnessing Photosynthesis - Zeakal
Unanticipated results can lead to great discoveries. Zeakal is a company founded by turning such an unexpected outcome into a promising biotechnology company. We conducted multiple interviews between 3 cities,…
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Podcast / Sep 30, 2019
Serial (Hard Science) Entrepreneurship - Sensulin
What is the difference between an entrepreneur and a serial entrepreneur? Is there a difference? We dig into this question with a four-time hard tech entrepreneur. Mike Moradi is the co-founder and CEO of…
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Podcast / Jul 11, 2019
TomorrowScale Podcast Preview
The TomorrowScale Podcast is a series of conversations with the scientists and leaders who are building the future. I am very excited to announce that we are in production on the first episodes of the…
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